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03 Oct: Diuretics: What New Trials Change

Generated October 2026 · Clinical Deep Dive 0 Comments At the American College of Cardiology’s 2026 Scientific Sessions, a trial called SPIRIT-HF delivered a genuinely unsettling result for one of cardiology’s oldest and cheapest drugs. Spironolactone, tested against placebo in patients with heart failure with preserved or mildly reduced ejection fraction…

03 Oct: Adverse Effect Rates Highest With Ibogaine, 5-MeO-DMT Use

TOPLINE Users of psychoactive substances ibogaine and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) reported higher rates of adverse health effects, including cardiac symptoms and suicidal thoughts, than users of psilocybin, lysergic acid diethylamide (LSD), or MDMA, a cross-sectional study showed. Psilocybin, LSD, and MDMA were estimated to affect a larger proportion of US adults than ibogaine or 5-MeO-DMT…