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Diuretics: What New Trials Change

Generated October 2026 · Clinical Deep Dive 0 Comments At the American College of Cardiology’s 2026 Scientific Sessions, a trial called SPIRIT-HF delivered a genuinely unsettling result for one of cardiology’s oldest and cheapest drugs. Spironolactone, tested against placebo in patients with heart failure with preserved or mildly reduced ejection fraction…

Adverse Effect Rates Highest With Ibogaine, 5-MeO-DMT Use

TOPLINE Users of psychoactive substances ibogaine and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) reported higher rates of adverse health effects, including cardiac symptoms and suicidal thoughts, than users of psilocybin, lysergic acid diethylamide (LSD), or MDMA, a cross-sectional study showed. Psilocybin, LSD, and MDMA were estimated to affect a larger proportion of US adults than ibogaine or 5-MeO-DMT…