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Post-trauma drug blocks fear response in female mice, study shows

Post-trauma drug blocks fear response in female mice, study shows

Nk3R antagonism decreases fear memory consolidation. (A) Experimental procedure of fear memory consolidation after stress. Created with Biorender. (B) Fear acquisition and expression in mice administered with Osanetant. (C) Effect in the fear memory consolidation after administration of Osanetant (5 mg/kg, ip) or Vehicle 30 min after stress (IMO) in adult females (n = 12

When to Prescribe GLP-1s? Earlier Might Be Better

The US Preventive Services Task Force (USPSTF) recommends that patients trying to lose weight should first try 6 months of behavior interventions that include a calorie-restrictive diet, weekly moderate to vigorous physical activity, self-monitoring of food intake, and removing unhealthy food triggers if possible. Yet many patients are unsuccessful at modifying their behaviors…

Smartwatch Motivates Patients With Diabetes to Stay Active

TOPLINE:  A recent study showed that a home-delivered physical activity intervention supported by wearable mobile health technology may help patients with newly diagnosed type 2 diabetes (T2D) adhere to physical activity routines, potentially leading to improvements in A1c levels and systolic blood pressure outcomes. METHODOLOGY:  Researchers conducted a randomised controlled trial to assess the feasibility

What Works for Low Back Pain? New Study Suggests Not Much

TOPLINE: Most nonsurgical and noninterventional treatments for low back pain failed to outperform placebo in a new systematic review and meta-analysis, with just 10% showing only modest pain relief. METHODOLOGY: Researchers conducted a systematic review and meta-analysis using randomized placebo-controlled trials of nonsurgical and noninterventional treatments for adults with nonspecific low back pain…

Bilateral ovary removal increases heart failure risk

Bilateral ovary removal increases heart failure risk

Credit: Unsplash/CC0 Public Domain Women of childbearing age who had both ovaries removed in a procedure called bilateral oophorectomy were more likely to develop heart failure later in life, according to a study being presented at the American College of Cardiology’s Annual Scientific Session (ACC.25). Bilateral oophorectomy is often recommended to treat, and in some