This diagram illustrates how the combination of fibroblast growth factor 4 and ascorbic acid activates the JAK2–STAT3 signaling pathway, promoting the maturation of induced cardiomyocytes (iCMs). This approach effectively reprograms fibroblasts into cardiomyocytes with improved structure and function, offering exciting possibilities for regenerative medicine. Credit: The authors Cardiovascular disease continues to lead as the primary
Credit: Pixabay/CC0 Public Domain Salt, or more precisely the sodium it contains, is very much a “Goldilocks” nutrient. Low sodium levels cause a drop in blood volume, which can have serious, sometimes deadly, health consequences. Conversely, too much salt can lead to high blood pressure and cardiovascular disease. In modern America, where most people consume
MedPage Today) — Self-reported physical function was better for long COVID patients after a brief outpatient program based on cognitive and behavioral therapy, a pragmatic trial in Norway showed. Scores on the Short-Form Health Survey 36 Physical…
The EHR Association is urging the agency to address members’ concerns and finalize additional decision support intervention measurements proposed in the draft rule, and clarify uncertainties that could compromise the quality of submissions…
Minor interventions are increasingly being rebranded and billed as surgery, for profit. This means a neurologist spending 40 minutes with a patient to tease out a diagnosis can be paid less for that time than a dermatologist spending a few seconds squirting a dollop of liquid nitrogen onto the skin…
MedPage Today) — Donald Trump was on the verge of backing a 16-week federal abortion ban earlier this year when aides staged an intervention. According to Time magazine’s cover story on his selection as its 2024 Person of the Year, Trump’s aides…
TOPLINE: The beneficial effect of clopidogrel monotherapy over aspirin monotherapy in patients who underwent percutaneous coronary intervention (PCI) and remained event free for 6-18 months on dual antiplatelet therapy (DAPT) is consistent, regardless of bleeding risk or PCI complexity, according to a post hoc analysis of the HOST-EXAM trial…
Graphical abstract. Credit: Nature Aging (2024). DOI: 10.1038/s43587-024-00753-6 Thirteen proteins linked to brain aging in humans are identified in a Nature Aging paper. Changes in the concentrations of these blood proteins may peak at 57, 70, and 78 years old in humans, and suggest that these ages may be important for potential interventions in the
MedPage Today) — SAN DIEGO — Increased dietary fiber had a significant association with improved outcomes in blood cancers, according to studies reported here. Patients undergoing allogeneic hematopoietic cell transplant (allo-HCT) had significantly…
Credit: Unsplash/CC0 Public Domain Researchers at Memorial Sloan Kettering Cancer Center (MSK) have reported results from the first-ever clinical trial demonstrating that a high-fiber, plant-based dietary intervention may delay progression to multiple myeloma, a rare and incurable blood cancer affecting the bone marrow. The study enrolled 20 participants with a precancerous blood disorder and an

