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Increased risk factors but not manifestation of disease correlated to placental inflammation

24 Nov: Increased risk factors but not manifestation of disease correlated to placental inflammation

WGCNA of placental villous RNA sequencing data identifies an inflammation-related gene expression module that is highly enriched in Hofbauer cells. Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-42300-8 Research led by McGill University, Canada, suggests that disruptions in Hofbauer cell function with preterm birth or intra-amniotic infection may contribute to traits associated with increased risk factors for