{"id":5536,"date":"2025-08-13T23:02:19","date_gmt":"2025-08-14T04:02:19","guid":{"rendered":"https:\/\/ahvmed.com\/?p=5536"},"modified":"2025-08-13T23:02:19","modified_gmt":"2025-08-14T04:02:19","slug":"widely-available-imaging-technique-can-improve-monitoring-and-treatment-of-atherosclerosis","status":"publish","type":"post","link":"https:\/\/ahvmed.com\/?p=5536","title":{"rendered":"Widely available imaging technique can improve monitoring and treatment of atherosclerosis"},"content":{"rendered":"
\n
18<\/sup>FDG-PET images show atherosclerotic activity in the abdominal aorta of pigs. The top two rows show anatomical CT images overlaid with a metabolic signal (18<\/sup>FDG), revealing active plaque metabolism. The bottom panels show cross-sectional images, including high-magnification views of the aortas. 18<\/sup>FDG uptake is low in healthy pigs (left), increases with untreated atherosclerosis (center), and falls after treatment, indicating reduced disease activity (right). Credit: CNIC”><\/p>\n
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\n CT and 18<\/sup>FDG-PET images show atherosclerotic activity in the abdominal aorta of pigs. The top two rows show anatomical CT images overlaid with a metabolic signal (18<\/sup>FDG), revealing active plaque metabolism. The bottom panels show cross-sectional images, including high-magnification views of the aortas. 18<\/sup>FDG uptake is low in healthy pigs (left), increases with untreated atherosclerosis (center), and falls after treatment, indicating reduced disease activity (right). Credit: CNIC
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Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) have shown that 18<\/sup>FDG-PET, an imaging technique widely used to study other conditions, can also be used to monitor atherosclerosis by measuring cellular metabolism within arterial plaques.<\/p>\n

The findings, published<\/a> in Science Translational Medicine<\/i>, could improve the clinical management of this disease and accelerate the development of new treatments.<\/p>\n

Atherosclerosis\u2014the underlying cause of most heart attacks and strokes\u2014is a silent disease that progresses over many years without symptoms. The disease is characterized by the accumulation of fatty deposits, cells, and other materials in the walls of arteries, where they reduce blood flow and can eventually rupture, triggering serious cardiovascular events. While treatments are available to slow disease progression, it is still difficult to determine if a treatment is working in individual patients.<\/p>\n

18<\/sup>FDG-PET (fluorodeoxyglucose positron emission tomography) is a nuclear imaging technique that uses a radioactively labeled glucose analog to detect tissue metabolic activity<\/a>.<\/p>\n

The new study demonstrates that the 18<\/sup>FDG-PET signal reflects the metabolic activity of atherosclerotic plaques, rather than merely indicating inflammation, as was previously believed.<\/p>\n

To reach this conclusion, the research team developed an experimental model of advanced atherosclerosis<\/a> in genetically modified animals and was able to partially reverse disease progression using a diet and drug-based intervention similar to strategies used in clinical care.<\/p>\n

As the disease regressed, the 18<\/sup>FDG-PET signal declined in parallel with the reduced expression of genes linked to glucose metabolism<\/a> in various plaque cell types, including macrophages, lymphocytes, and smooth muscle cells<\/a>.<\/p>\n

“The 18<\/sup>FDG-PET signal reflects the activity level of the cells within atherosclerotic lesions<\/a> and can therefore serve as a sensitive tool for evaluating treatment efficacy and disease progression risk,” explains CNIC researcher Paula Nogales, lead author of the study together with Jacob Bentzon, of Aarhus University (Denmark) and head of the Experimental Pathology of Atherosclerosis group at the CNIC.<\/p>\n

This discovery opens the door to using a widely available hospital imaging technique<\/a> to improve clinical monitoring of atherosclerosis and speed the development of new therapies for this silent but potentially deadly disease.<\/p>\n

\n

More information:<\/strong>
\n Paula Nogales et al, Atherosclerotic disease activity is associated with glycolytic enzyme expression across multiple cell types and is trackable by FDG-PET, Science Translational Medicine<\/i> (2025). DOI: 10.1126\/scitranslmed.ado6467<\/a>. www.science.org\/doi\/10.1126\/scitranslmed.ado6467<\/a><\/p>\n<\/p><\/div>\n

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Citation<\/strong>:
\n Widely available imaging technique can improve monitoring and treatment of atherosclerosis (2025, August 13)
\n retrieved 14 August 2025
\n from https:\/\/medicalxpress.com\/news\/2025-08-widely-imaging-technique-treatment-atherosclerosis.html\n <\/p>\n

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CT and 18FDG-PET images show atherosclerotic activity in the abdominal aorta of pigs. The top two rows show anatomical CT images overlaid with a metabolic signal (18FDG), revealing active plaque metabolism. The bottom panels show cross-sectional images, including high-magnification views of the aortas. 18FDG uptake is low in healthy pigs (left), increases with untreated atherosclerosis<\/p>\n","protected":false},"author":163,"featured_media":5537,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":{"0":"post-5536","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-medicalnewstoday_com"},"menu_order":0,"_links":{"self":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/posts\/5536","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/users\/163"}],"replies":[{"embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5536"}],"version-history":[{"count":0,"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/posts\/5536\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/media\/5537"}],"wp:attachment":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5536"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5536"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5536"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}