{"id":4765,"date":"2023-07-22T15:33:13","date_gmt":"2023-07-22T20:33:13","guid":{"rendered":"https:\/\/heartandvascularmed.com\/?p=4765"},"modified":"2023-07-22T15:33:13","modified_gmt":"2023-07-22T20:33:13","slug":"researchers-pave-the-way-for-individualized-obesity-therapy-tailoring-interventions-to-a-persons-needs","status":"publish","type":"post","link":"https:\/\/ahvmed.com\/?p=4765","title":{"rendered":"Researchers pave the way for individualized obesity therapy, tailoring interventions to a person&#8217;s needs"},"content":{"rendered":"<div>\n<div data-thumb=\"https:\/\/scx1.b-cdn.net\/csz\/news\/tmb\/2023\/obesity-3.jpg\" data-src=\"https:\/\/scx2.b-cdn.net\/gfx\/news\/hires\/2023\/obesity-3.jpg\" data-sub-html=\"Credit: Pixabay\/CC0 Public Domain\">\n<figure>\n            <img src=\"https:\/\/scx1.b-cdn.net\/csz\/news\/800a\/2023\/obesity-3.jpg\" alt=\"obesity\" title=\"Credit: Pixabay\/CC0 Public Domain\" width=\"800\" height=\"530\"><figcaption>\n                Credit: Pixabay\/CC0 Public Domain<br \/>\n            <\/figcaption><\/figure>\n<\/p><\/div>\n<p>In a pilot study of 165 people, Mayo Clinic researchers looked at the effectiveness of two different approaches to weight loss: a standard lifestyle intervention and individualized therapy. The standard lifestyle intervention included a reduced diet, exercise and behavior therapy. The individualized approach was based on phenotypes and included different interventions depending on the person&#8217;s predominant underlying cause of obesity. A diet based on phenotypes considers a person&#8217;s genetic and phenotypic characteristics to create a tailored eating plan meant to optimize health and well-being.\n                                                <\/p>\n<p>The researchers compared whether diet and lifestyle interventions tailored to obesity phenotypes would work better than standard lifestyle interventions on <a href=\"https:\/\/medicalxpress.com\/tags\/weight+loss\/\" rel=\"tag\">weight loss<\/a>, <a href=\"https:\/\/medicalxpress.com\/tags\/cardiometabolic+risk+factors\/\" rel=\"tag\">cardiometabolic risk factors<\/a> and physical variables contributing to obesity. Cardiometabolic health describes the connection between the heart and <a href=\"https:\/\/medicalxpress.com\/tags\/blood+vessels\/\" rel=\"tag\">blood vessels<\/a> and the body&#8217;s energy and chemical processes. It covers a wide range of disorders and risk factors that contribute to <a href=\"https:\/\/medicalxpress.com\/tags\/heart+disease\/\" rel=\"tag\">heart disease<\/a> and metabolic syndrome.\n<\/p>\n<p>In adults with obesity, the phenotype-tailored lifestyle interventions resulted in more weight loss than the standard lifestyle interventions of a reduced-calorie diet, exercise and behavior therapy.\n<\/p>\n<h2>Findings after 12 weeks included:<\/h2>\n<ul>\n<li>Patients who used phenotype-tailored lifestyle interventions did better in treating their obesity than those who used standard lifestyle interventions.<\/li>\n<li>The phenotype-focused group of patients had more significant weight loss, reduced <a href=\"https:\/\/medicalxpress.com\/tags\/waist+circumference\/\" rel=\"tag\">waist circumference<\/a>, reduced triglycerides, reduced daily caloric intake and less anxiety.<\/li>\n<li>They had a substantial increase in lean mass percentage.<\/li>\n<li>They also had a lesser decrease in the number of calories required by the body during resting conditions.<\/li>\n<\/ul>\n<p>&#8220;The results stress the relevance of identifying the underlying cause of obesity as a complex disease with many factors,&#8221; says Andre Acosta, M.D., Ph.D., a Mayo Clinic obesity researcher and the study&#8217;s last author.\n<\/p>\n<h2>What is a phenotype-tailored intervention?<\/h2>\n<p>Obesity phenotypes are based on the cause of the disease and behavioral components and include three main areas:\n<\/p>\n<ul>\n<li>Homeostatic eating\u2014eating in response to a perceived energy need by the brain.<\/li>\n<li>Hedonic eating behavior\u2014consuming foods for pleasure, not for physical hunger or energy needs.<\/li>\n<li>Abnormal energy expenditure\u2014the number of calories burned in 24 hours compared to an average person.<\/li>\n<\/ul>\n<p>Four actionable <a href=\"https:\/\/medicalxpress.com\/tags\/phenotypes\/\" rel=\"tag\">phenotypes<\/a> of these areas include abnormal fullness, measured by calories ingested to experiencing unpleasant fullness; abnormal duration of fullness; emotional eating behavior; and abnormal resting energy expenditure.\n<\/p>\n<p>The researchers reported that people who used the phenotype-tailored <a href=\"https:\/\/medicalxpress.com\/tags\/lifestyle+interventions\/\" rel=\"tag\">lifestyle interventions<\/a> showed significant improvement in some targeted areas, such as abnormal fullness and emotional eating.\n<\/p>\n<p>&#8220;The results of this study support the need for an actionable, phenotype-based classification [of patients in obesity treatment] rather than relying only on the number on the scale, body measurements or [if they have] obesity-related diseases, such as heart disease, <a href=\"https:\/\/medicalxpress.com\/tags\/high+blood+pressure\/\" rel=\"tag\">high blood pressure<\/a> and certain cancers,&#8221; says Dr. Acosta.\n<\/p>\n<h2>Opportunities for further research<\/h2>\n<p>Dr. Acosta says more research is needed to assess the long-term effect of a phenotype-based approach. In particular, further studies may need to look at other physical and metabolic variables to understand people with no identified phenotype.\n<\/p>\n<p>Dr. Acosta also notes that the effects of therapy on the two approaches must be examined independently. People with an emotional eating component received a more intense intervention, with 24 behavior modification sessions, to address this underlying trait that may have a leading role in obesity development.\n<\/p>\n<p>&#8220;More research will enhance the tailored approach proposed from the data,&#8221; says Dr. Acosta. &#8220;We will continue to work on individualized obesity therapy directed at specific traits to identify the right therapy for the right patient.&#8221;<\/p>\n<div>\n<p><strong>More information:<\/strong><br \/>\n                                                    Lizeth Cifuentes et al, Phenotype tailored lifestyle intervention on weight loss and cardiometabolic risk factors in adults with obesity: a single-centre, non-randomised, proof-of-concept study, <i>eClinicalMedicine<\/i> (2023).  <a data-doi=\"1\" href=\"https:\/\/dx.doi.org\/10.1016\/j.eclinm.2023.101923\" target=\"_blank\" rel=\"noopener\">DOI: 10.1016\/j.eclinm.2023.101923<\/a><\/p>\n<\/p><\/div>\n<div>\n<p><strong>Citation<\/strong>:<br \/>\n                                                 Researchers pave the way for individualized obesity therapy, tailoring interventions to a person&#8217;s needs (2023, July 21)<br \/>\n                                                 retrieved 22 July 2023<br \/>\n                                                 from https:\/\/medicalxpress.com\/news\/2023-07-pave-individualized-obesity-therapy-tailoring.html\n                                            <\/p>\n<p>\n                                            This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no<br \/>\n                                            part may be reproduced without the written permission. The content is provided for information purposes only.\n                                            <\/p>\n<\/p><\/div><\/div>\n<p><a href=\"https:\/\/medicalxpress.com\/news\/2023-07-pave-individualized-obesity-therapy-tailoring.html\" class=\"button purchase\" rel=\"nofollow noopener\" target=\"_blank\">Read More<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Pixabay\/CC0 Public Domain In a pilot study of 165 people, Mayo Clinic researchers looked at the effectiveness of two different approaches to weight loss: a standard lifestyle intervention and individualized therapy. The standard lifestyle intervention included a reduced diet, exercise and behavior therapy. The individualized approach was based on phenotypes and included different interventions<\/p>\n","protected":false},"author":181,"featured_media":4766,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[53],"tags":[],"class_list":{"0":"post-4765","1":"post","2":"type-post","3":"status-publish","4":"format-standard","5":"has-post-thumbnail","7":"category-medicalnewstoday_com"},"menu_order":0,"_links":{"self":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/posts\/4765","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/users\/181"}],"replies":[{"embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4765"}],"version-history":[{"count":0,"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/posts\/4765\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=\/wp\/v2\/media\/4766"}],"wp:attachment":[{"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4765"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4765"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ahvmed.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4765"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}